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Cancers of the Colon, Rectum and Anus

Colorectal cancer (or bowel cancer) is one of the most common types of cancer in both men and women. Approximately four fifths of these cancers are found in the colon (large intestine), and one fifth in the rectum. Prevention and early detection of colorectal cancer is important. Some of most common symptoms include a change in bowel habit (eg. constipation, and bleeding), mucus discharge, and discomfort or pain in the lower abdomen. The vast majority of colon and rectum cancers are adenocarcinomas, around 10% of these are mucinous (protein contained in mucus). The median age at diagnosis is 70, age adjusted incidence rates are slightly higher in males compared to females. A substantial proportion of cases are in those with a genetic predisposition to colorectal cancer. Diet may also have an influence on the incidence of colorectal cancer, diatry fibre, retinoids, and calcium are thought to be protective, while high intake of animal fats may increases risk. Colorectal cancer may develop from benign polyps (a polyp is a tumour on a stem most commonly found on mucous membranes). World-wide about 782,000 people are diagnosed with colorectal cancer each year.

 

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Information for Patients and the Public

Information for Health Professionals

 

Screening and Prevention

Prevention and early detection of colorectal cancer is important, many patients do not show symptoms until the disease has reached an advanced stage; screening may help detect changes before they become cancerous, or catch the cancer at an early stage. Screening may by targeted at populations thought to have a higher risk of developing colorectal cancer (for example those over age 50, particularly those with a 1st degree relative dignosed with colorectal cancer, or familial predispostion to adenomatous polyposis).

Genetic Information

Between 15-20% of all colorectal cancers are thought to be familial. Some types of colon cancers and pre-disposing conditions are known to have an inherited element, in particular, hereditary non-polyposis colon cancer (HNPCC) and familial adenomatous polyposis (FAP).

Anal Cancer

Anal cancer is an uncommon cancer, in which malignant cells are found in the anus (the opening at the end of the rectum through which the body passes waste). Cancer in the outer anus is more frequent in men, whilst cancer in the inner part of the rectum (the anal canal) is more frequent in women.

 

Research: Virtual Colonoscopy

"Virtual colonoscopy" (VC) is a new technique that uses computed tomography and advanced imaging techniques to produce three dimensional views of the colonic mucosa similar to those of a "real" colonoscopy. As this non-invasive technique develops research is being undertaken to test how sensitive it is in detecting polyps and early colon cancer.

Selected references


Fenlon HM, et al. A Comparison of Virtual and Conventional Colonoscopy for the Detection of Colorectal Polyps N Engl J Med 1999; 341:1496-503    Related articles

Halligan S, Fenlon HM Virtual colonoscopy. [Editorial] BMJ 1999; 319(7219):1249-1252    Related articles

Sonnenberg A, et al. Is virtual colonoscopy a cost-effective option to screen for colorectal cancer? Am J Gastroenterol. 1999; 94(8):2268-74    Related articles (PubMed)

Medline Search: virtual colonoscopy AND colorectal cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

 

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